Modeling Metastatic Colonization in a Decellularized Organ Scaffold‐Based Perfusion Bioreactor (Adv. Healthcare Mater. 1/2022)
نویسندگان
چکیده
Cancer Metastasis Highlighting article number 2100684 by Janine T. Erler, Alejandro E. Mayorca-Guiliani and co-workers, this cover represents cancer cells extravasating out of a vessel into decellularized extracellular matrix (ECM) organ scaffold. Upon arriving in the capillary bed, adhere to ECM use it migrate organ. The authors' metastasis model system is based on bioreactor where scaffolds are provided with conditions necessary sustain cell life. Cell-ECM interactions coerce behaving as they would living organism.
منابع مشابه
Preservation of biomacromolecular composition and ultrastructure of a decellularized cornea using a perfusion bioreactor
An attempt has been made to formulate a new method of corneal decellularization using a direct perfusion system through the cornea. Here, we compared the direct perfusion method to some commonly used decellularization strategies including chemical methods; non-ionic detergent TRITON X-100 and ionic detergent; sodium dodecyl sulphate (SDS) based orbital shaker method and physical methods of liqu...
متن کاملRole of fibulin-5 in metastatic organ colonization.
The tumor microenvironment is now recognized as a major factor in determining the survival and growth of disseminated tumor cells at potential metastatic sites. Tumor cells send signals to stroma cells and stimulate them to produce factors that in turn create favorable conditions for tumor cell metastasis. Activated fibroblasts constitute an important component of the tumor-associated stroma. W...
متن کاملMetamaterials: Snapping Mechanical Metamaterials under Tension (Adv. Mater. 39/2015).
By exploiting snap-through instabilities, D. Pasini and co-workers design a damage-tolerant mechanical metamaterial that snaps sequentially under tension, thereby accommodating a very large deformation up to 150%. On page 5931, they describe how the nonlinear mechanical response of the metamaterial can be robustly programmed by tuning the architecture of its unit cell.
متن کاملTowards the creation of decellularized organ constructs using irreversible electroporation and active mechanical perfusion
BACKGROUND Despite advances in transplant surgery and general medicine, the number of patients awaiting transplant organs continues to grow, while the supply of organs does not. This work outlines a method of organ decellularization using non-thermal irreversible electroporation (N-TIRE) which, in combination with reseeding, may help supplement the supply of organs for transplant. METHODS In ...
متن کاملOsteogenic Differentiation and Mineralization on Compact Multilayer nHA-PCL Electrospun Scaffolds in a Perfusion Bioreactor
Background: Monolayer electrospun scaffolds have already been used in bone tissue engineering due to their high surface-to-volume ratio, interconnectivity, similarity to natural bone extracellular matrix (ECM), and simple production. Objectives: The aim of this study was to evaluate the dynamic culture effect on osteogenic differentiation and mineralizationi into a compact cellular multilayer ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Advanced Healthcare Materials
سال: 2022
ISSN: ['2192-2640', '2192-2659']
DOI: https://doi.org/10.1002/adhm.202270001